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Formulation and evaluation of Liquisolid tablet of Budesonide

Author: 
Aher, S. S., Pagar, P. R. and Saudagar, R. B.
Subject Area: 
Health Sciences
Abstract: 

The limited solubility of drugs is a challenging issue for industry, during the development of the solid dosage form. Liquisolid technique is a novel and promising approach to overcome this problem. This technique is an efficient method for formulating water insoluble and poorly water soluble drugs. The liquisolid technique is based upon the dissolving the insoluble drug in the nonvolatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powder. The use of non-volatile solvent causes improved wettability and ensures molecular dispersion of drug in the formulation and leads to enhance solubility. Purpose of this study is to develop novel liquisolid technique to enhance the dissolution rate of Budesonide. Liquisolid tablet prepared by using Avicel PH 102, Aerosil 200 and sodium starch glycolate were employed as carrier, coating material and disintegrant respectively. The interaction between drug and excipients in prepared LS compacts were studied by differential scanning calorimetry (DSC) and Powder X- ray diffraction (PXRD).The prepared LS compacts were evaluated for their flow properties such as bulk density, tapped density, angle of repose, Carr’s compressibility index and Hausner’s ratio. The drug release rates of LS compacts were distinctly higher as compared to directly compressed conventional tablets, which show significant benefit of LS in increasing wetting properties and surface area of drug available for dissolution. LS compact system showed acceptable flowability, Carr’s compressibility index and Hausner’s ratio. The DSC and XRD studies conforms the no significant interaction between the drug and excipients used in LS compacts. From this study it concludes that the LS technique is a promising alternative for improvement of dissolution property of water-insoluble drugs.

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