The present study categorically aimed at understanding the effects and impact of Hiv/Aids, drugs and substance abuse among the youth who are in aged bracket between 15 and 25 years. As the accurate data on youth involved in substance abuse in the city are not available, it may be difficult to determine the overall comprehensive perspective of the study due to relative responses from the sample respondents among youth in Visakhapatnam, A.P., India. It is worth discussing the magnitude of impact of HIV/AIDS, drugs and substance abuse among the youth in Visakhapatnam. According to the most recent study, it revealed that estimates of approximately 200,000 drug-injecting-related deaths may occur per annum based on the estimated size of the current world population of injecting drug abusers of at least 5.3 million. World Health Organization (WHO) reported that a multi-fold increase in drug-related deaths over the past decade occurred. The yearly mortality rates or "lethal impact" among intravenous drug users or drug addicts on treatment programmes ranged between one and two percent which primarily transpired in the younger generations. In addition to its adverse effects on health, injury and eventual death, drugs is among the most prevalent associated with HIV/AIDS). This social problem requires primary health and structural reforms to enhance the level of treatment, rehabilitation and prevention.