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Hormone therapy for breast cancer

Author: 
Saleh M. Ruzan, Saleh M. Sama, Alhasan H. Ahmed and Al-Nazzawi T. Mohammed
Subject Area: 
Health Sciences
Abstract: 

Background: Breast cancer is the most common cancer in women worldwide. Most women with newly diagnosed breast cancer are of luminal type. Aim: To explore the modern modalities focusing on the hormone therapies for breast cancer. Methods: Systemic review of PubMed filter finds publications to support keywords of the current study. Findings: Treatment of breast cancer can be classified into local or systemic therapies. Local therapies like Surgery, Radiotherapy, However systemic treatment includes chemotherapy, Targeted therapy by anti-HER2 blockade and endocrine treatment that involves selective estrogen receptor modulators (SERM), aromatase Inhibitors (AI), fulvestrant, and ovarian suppression. Recent studies recommends that higher-risk patients should receive ovarian suppression in addition to adjuvant endocrine therapy, whereas lower-risk patients should not. Women with stage II or III breast cancers who would ordinarily be advised to receive adjuvant chemotherapy should receive ovarian suppression with endocrine therapy. Conclusion: Hormonal therapy of breast cancer is personal, women with stage I breast cancers not warranting chemotherapy should not receive ovarian suppression, nor should women with node-negative cancers 1 cm or less. Ovarian suppression is effective and may be administered with either tamoxifen or an aromatase inhibitor.

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