The present study was planned to know the effect of mixed aqueous extract of piper nigrum & zingiberofficinale in high fat diet (HFD) induced hyperlipidemic albino rats. Phytochemical analysis was done separately on each aqueous extract. Alkaloids, saponins, tannins, phlobatanins, anthrax quinones, & cardenolides were found in both plants where as cardiac glycosides, steroids, &terpenoids were absent. Forty albino rats were randomly distributed into four groups (A-D) of ten albino rats each. All were fed with high fat diet (HFD) & water ad libitum. Group A was negative control group& Group D was positive control group and were not administered any extract. Whereas Group B & Group C were test groups, treated by mixed aqueous extract (P.Nigrum + Z.Officinale) at 400mg/kg.body weight & 800mg/kg.body weight respectively for forty-two days.The results showed that the treatment with mixed aqueous of ZO & PN at a dose of 800mg/kg body weight successfully reduced the elevated serum lipids more than the dose of 400mg/kg.body weight & that of simvastatin.These findings indicate that the mixed aqueous extract of ZO & PN can be used in hyperlipidaemia, a major cause of CVD. Thus, herbs PN & ZO may be useful in future as a leading compound for development of new drugs, after clinical trials.
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