Specialty cosmetic formulations are meant for certain unique benefits that are linked closely with therapeutic effect and hence such formulations require high level of safety considerations. The cosmetic formulations meant for dry skin in Psoriasis, dry eczema, Atopic dermatitis, Ichthyosis vulgaries type conditions need to be very safe as the skin of these patients is very sensitive. More over the Psoriasis, Atopic dermatitis, eczema are auto immune diseases and the products for these should not have the potential for irritancy. The current study was done on human subjects to check the skin irritancy nature and potential for skin irritancy by skin irritancy test and skin sensitization test. Results are presented in the article.