Background: Malaria and other mosquito vector born diseases prevalent globally. In India, village people often have no or limited hospital facility at their places. Further due to the lack of proper knowledge, local village people have to rely on traditional medicines for treatment of the disease. Ethnomedicinal plants and animals commonly used by tribal people to cure malaria and other fever, in the Meikal hill region of Amarkantak were surveyed and documented. Method: The present investigation is based on a survey of local medicines in and around Amarkantak region and their documentation. Result: The study revealed that plants like Van Adarak- zingiber zerumbet (L.) Zingiberceae, kalmegh- Andrographispaniculata Acanthaceae, Vanjira- Centratherum Asteraceae, Sudarsan- Crinum asiaticum Amarryllidaceae, Asplenium nidus L. and some special fish species and fish oil are used in the form of decoction, powder, paste and juice for the control of Malaria and other diseases by tribal people. These formulations were found to be effective and needing further scientific validation. Conclusion: Traditional tribal medicines that are used by the tribal peoples for the treatment of malaria fever and other fever is very effective. Their fore, it is very necessary that is made documentation of tribal medicines for the generation of new medicine that may be possible to control new communicable & vector born diseases like malaria, swine flu, bird flu, etc.