CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Increased frequency of hla-drb1*12 in asthma patients visiting a teaching hospital lahore, Pakistan

Author: 
Khursheed Javed, Nadeem Afzal, Faheem Shahzad, Saleem-u-Zaman, Saba Khaliq, Shah Jahan, Waqas Latif, and Shaguftta Khalid
Subject Area: 
Health Sciences
Abstract: 

Background: Throughout the world, there are more than 300 million people of asthma and its prevalence in Pakistan is 3.7%. In Pakistan, there are studies on association of HLA with different diseases but data about HLA association with bronchial asthma is limited. An Iranian study described increased frequency of DRB1*12 allele in asthmatic patients. Therefore, present study was designed to determine frequency of HLA-DRB1*12 allele in patients of bronchial asthma. Material and Method: Fifty clinically-diagnosed bronchial asthma patients between 18-40 years with the history of allergy and 30 healthy subjects were selected. HLA-DRB1*12 allele and total serum IgE level was determined by PCR and ELISA technique respectively. Student-t test was applied to observe group mean difference. A p-value of ≤0.05 was considered statistically significant. Results: Frequency of HLA-DRB1*12 allele in asthma patients was high (42%) compared to controls (20%) and on comparison there was statistically significant difference (p=0.04). Mean ± SD of total serum IgE level of bronchial asthma patients was high (861.6 ± 559.2 IU/ml) compared to controls (204.7 ± 237 IU/ml) and on comparison there was statistically significant difference (p = <0.001). Mean ±SD of total IgE level in HLA-DR B1*12 positive asthma patients was high (607.9 IU/ml) compared to HLA-DR B1*12 negative asthma patients (518.4 IU.ml) and on comparison there was no significant difference. Conclusion: Frequency of HLA-DRB1*12 was increased in bronchial asthma patients but this allele did not confer susceptibility to the raised total serum IgE levels.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran