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The influence of the mucins in genetic balance in oral and laryngeal cancer and by their biochemical behaviour a working hypothesis for their care

Author: 
Menicagli, R., Duca, M., Rancoita, P. M. V. and Arizzi, C. E
Subject Area: 
Health Sciences
Abstract: 

Back Ground and Objectives: The most recent genetic research have identified key genes that may be promoting the formation of tumors of the oral cavity and larynx, regardless of external factors such as smoking and HPV. The aim of this paper is to verify whether the importance of the genetic factor is very dependent on the parameters affecting the oral defenses drop, mostly on mucins. Study Material: Was conducting a review for 2015-2016 year with databases PUB MED, GENE, and HOME Genetic References, using key word and key stream "oral and laryngeal cancer genetic in 2015 and 20216 year to identify potential genes involved. The data were compared with the most recent review that also takes into account the two most important external causes smoking and HPV. According to a previous our study, have been identified, but also the incidence of other factors regarding the onset of oral cancer and larynx. The applicability and verification of these results even after a posterior effective bibliographic update has been tested on a sample of thirty laryngectomees patients, through the administration of a questionnaire Results and Discussion: even if with some differences the type and the number of genes involved, are broadly similar to those identified in a recent review. Statistical analysis of the results obtained by processing the questionnaire, confirmed that the l smoke autoimmune disorders and certain environmental conditions and lifestyles, can inactivate and/or deprive the Mucinic Fraction. To observe that the proportion of patients with laryngeal cancer presenting an autoimmune disease is higher than the contro group (0.012 with Fisher Exact test) and also versus to general population given in Italian (36% vs 1%) with p value < 0.001, with a test of proportions. Also during those same PCs smoking and the presence of an autoimmune disease are twonot associated risk factors (p = 0.1211 with fisher's exact test). Among all autoimmune conditions, according very recent epidemiological studies, diabetes, in the sample of laryngectomized patients is higher tha the control group, but with p value =0.195. The results also that xerostomia is in larynctomees group a sign very important were the p-value is 0.012 with large influence in men ,p-value = 0.054 indicate Conclusions and Proposals: The etiology of cancer of the oral cavity and larynx is multifactorial. and seem to depend for different geographical areas, from food use/abuse, sexual mores and lifestyles and also by the increase in diabetes. The crucial protective function of mucins that altered in various carcinomas resulting in hyper expression, provides the original idea for a proposal to fight the tumor. You could use an oncogenic virus "attenuated" improved in capsid with the enzyme neuroaminidase, to delete the links-sialic acid mucin. Interrupting hyperespressivity and consequently the process of angiogenesis, facilitating their entry into cells and the tumor suppressor p53, engineered viral DNA may then suppress carcinogenesis

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