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An insight into gene therapy - the forefront of medicine

Author: 
Dr. Mahima V. G., Dr. Karthikeya Patil and Dr. Srishti Tayal
Subject Area: 
Health Sciences
Abstract: 

Gene therapy focuses at introduction of a defined DNA sequence into particular cells of a patient either to substitute a faulty gene, or to accord a new function to the cell for secretion of protein with alleged therapeutic function. The term ‘gene transfer’ refers to the delivery of a gene, a cDNA, a small RNA, that is, any type of oligonucleotide that might have some therapeutic benefit, to a predetermined target cell. Gene therapy allows specific gene products to be delivered to a precise anatomic location. In addition, the level of transgene expression as well as the duration of expression can be regulated with current techniques. The purpose of this review is to give a brief insight into the gene transfer principles, mechanisms and strategies for correcting various diseases.

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