Exophytic gingival lesions represent some of the more frequently encountered lesions in the oral cavity. Pyogenic granuloma is a primarily reactive hyperplasia which appears in the oral cavity as an overgrowth of tissue due to physical trauma or hormonal factors and irritation. The growth is typically seen in young adults, it may occur in any age, especially in individuals with poor oral hygiene. The purpose of this article is to present a case report of pyogenic granuloma in male patient with mandible involvement.