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Phylogenetic analysis and homology modelling of promising ligands for the treatment of acute lymphoblastic leukemia

Author: 
Padmavathy, A., Dr. Ravindernath, A. and Smt. P. Sahithi
Subject Area: 
Life Sciences
Abstract: 

Nucleic acids control heredity on a molecular level and enzymes like L-asparaginase catalyses the conversion of L-asparagine to L-aspartate. L Asparaginase catalyzes the hydrolysis of the non-essential amino acid L-Asn to L-Asp and ammonia and is widely used for the treatment of hematopoietic diseases such as acute lymphoblastic leukemia (ALL) and lymphomas. In the present work, we focus on the characteristic of the enzyme (family of glycosidase) L-Asparaginase that bears E.C.No 3.5.1.1 and its properties. Acute lymphoblastic leukemia is a cancer that starts from early version of white blood cells called lymphoblastic leukemia in the bone marrow and in silico tools were employed in the present study for the phylogenic analysis of the enzyme L-Asparaginase like CLUSTAL X, CLUSTAL W, GENE BEE, EMBOSS NEEDLE, MEGA and insilico docking studies of ligand structures obtained from Pubchem. Database 3.3 version, a new version of Easy Modeller (Easy Modeller 4.0) has been used for the modeling analysis. The target sequence utilized is a hypothetical human L-Asparaginase sequence bearing accession no: AAM28434.1. Four species were examined rat, chimpanzee, fruit fly & human with fish with percentages obtained as Humans with mouse = 92-94 % identity, Humans with chimpanzee =98 % identity, Humans with fruit fly = 42% identity &Humans with fish = 63 % identity. Ramachandran plots were analyzed via procheck and model no.3 was the best model plot.The data generated for the Insilico analysis of ALL (acute lymphoblastic leukemia) can also find further scope in other dreadful diseases.

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