Secondary metabolites are valuable source for drug preparation. Phytochemical analysis of methanolic extract of Ceropegia bulbosa showed presence of alkaloids, carbohydrates, glycosides, phenolic compounds, flavonoids, proteins and amino acids, saponins, sterols, and, terpenoids. The gas chromatography- mass spectrometry of methanolic leaf extract showed Pentadecanoic acid having highest area % of 10.09 with retention time 16.105 followed by Octadecanoic acid with area % of 2.43, retention time 18.049 followed by 2,3-dihydro-3,5-dihydroxy-6- methyl-4H-Pyran with area % of 0.55, retention time 7.125 followed by Tetradecanoic acid with area % of 0.45, retention time 15.002 followed by Heptadecanoic acid with area % of 0.31, retention time 18.097 followed by 1-Octadecene with area % of 0.16, retention time 15.297. The present study shows that the methanolic extract of Ceropegia bulbosa have important bioactive compounds which can play a significant role in drug development.