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Postnatal Developmental Toxicity Of Crocus Sativus (Saffron) In Wistar Rats

Author: 
Ramesh Edamula, Deecaraman, M., Vijayalakshmi, M., Santhosh Kumar, D. P., Krishnamurthy, H. N. and Krishnappa, H.
Subject Area: 
Life Sciences
Abstract: 

The postnatal developmental toxicity of Crocus sativus (saffron) was evaluated in a mammalian species taking Wistar rat as the model. Saffron administered as an oral gavage from implantation (day 5 post coitus) through lactation up to lactation day (LD) 20 at the doses of 50, 250 and 1000 mg/kg/day did not elicit any effects on maternal/lactation body weight gains, food intake and fertility. The mean number of pups born and weight of male and female pups and pup’s survivability were unaffected. The results obtained conclude that saffron did not induce any maternal toxicity or any toxicity on the developing fetus/pups including its survivability and hence saffron is considered to have no postnatal developmental toxicity potential.

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