Background and Aim: Canine parvovirus (CPV) infection is the most highly infectious and contagious viral disease in dogs. Dogs of all age groups are susceptible but puppies of age less than 3 months are highly susceptible than adults. The current study was based on hospitalized patients, so a comprehensive study including all the dog population is required to precisely conclude about the prevalence and risk factors of CPV infections both in Bangladesh and India. Design and Methods: The hospitalized dogs were considered as study population. In CVASU and VCRI-MVC about 50 and 110 dogs of different breeds (indigenous and exotic breed i.e. Spitz, Pug, Doberman, Rottweiler and GS were clinically examined respectively during the study period. Total no of dogs were separated into different categories such as age, sex, breed and vaccination status. Statiscal analysis: All the data including categorical variables –age, sex, breed, vaccination status, dehydration, bloody diarrhoea and diagnosis were entered into MS excel (Microsoft Office Excel-2010). Then the data was finally analyzed using statistical software STATA Version-11 (STATA Corporation, College Station, Texus). Results: Prevalence of CPV infection was higher in India than Bangladesh. Among different risk factors young, unvaccinated puppies, female dog, exotic breeds were more prone to CPV infection. Conclusions: Canine Parvovirus is an infectious and highly contagious viral disease of dogs. Dogs of all age groups are infected but puppies age less than 3 months are highly susceptible than adults. CPV infection was mainly diagnosed by taking clinical history from owner and by observing the clinical findings. If confirmatory diagnosis was done then the result would be more precise.