In globally growing of dental treatment provider’s, while providing best treatments to the patient, it is extremely important for a dentist to follow a protocol to facilitate cross infection control in the office and to prevent cross-contamination between the patients, dentists, assistants, and paramedical staff, yet cross contamination and its modes still remain the same. To ensure risk free practice it is essential to follow the two basic R’s: Reduce –the infection, Reevaluate the status. This article emphasizes fundamentally on different pathways of cross infection and methods that can be implemented in an attempt to remove but at least reduce creating an ideal situation to prevent cross contamination. Personal protection, decontamination and formulation of an infection control policy have been discussed