Preventive efficacy of eugenol on isoniazid and rifampicin induced hepatotoxic rats

Anti-tuberculosis drug induced hepatotoxicity is a major hurdle for an effective treatment of tuberculosis. The present study was aimed to assess the preventive effect of eugenol (6mg/kg bw and 12mg/kg bw) on isoniazid (50mg/kg bw) and rifampicin (100mg/kg bw) induced hepatotoxicity was manifested by a significant increase in the activities of marker enzymes (AST, ALT, ALP, LDH and GGT) level in serum. The activities of enzymic (SOD, CAT, GST and GPx) and non enzymic antioxidants (VitC, Vit E and GSH) were reduced by the antitubercular drugs. Pretreatment of rats with eugenol reversed these altered parameters to near normal values. Results of this study revealed that eugenol encounter a significant defend in the mitigation of isoniazid and rifampicin induced hepatotoxicity.