Categories
- Indexing & Abstracting
- Editorial Board
- Submit Manuscript
- Instruction to Author
- Current Issue
- Past Issues
- Call for papers June 2021
- Ethics and Malpractice
- Conflict of Interest Statement
- Statement of Informed Consent
- Final Proof Correction and Submission
- Publication Ethics
- Peer review process
- Cover image - April 2021
- Quick Response - Contact Us
CALL FOR PAPERS
Author Information
CERTIFICATE
IMPACT FACTOR 2019
Subject Area
- Life Sciences / Biology
- Architecture / Building Management
- Asian Studies
- Business & Management
- Chemistry
- Computer Science
- Economics & Finance
- Engineering / Acoustics
- Environmental Science
- Agricultural Sciences
- Pharmaceutical Sciences
- General Sciences
- Materials Science
- Mathematics
- Medicine
- Nanotechnology & Nanoscience
- Nonlinear Science
- Chaos & Dynamical Systems
- Physics
- Social Sciences & Humanities
Why Us? >>
- Open Access
- Peer Reviewed
- Rapid Publication
- Life time hosting
- Free promotion service
- Free indexing service
- More citations
- Search engine friendly
Plagiarism Detection
IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.
Preventive efficacy of eugenol on isoniazid and rifampicin induced hepatotoxic rats
Subject Area:
Life Sciences
Abstract:
Anti-tuberculosis drug induced hepatotoxicity is a major hurdle for an effective treatment of tuberculosis. The present study was aimed to assess the preventive effect of eugenol (6mg/kg bw and 12mg/kg bw) on isoniazid (50mg/kg bw) and rifampicin (100mg/kg bw) induced hepatotoxicity was manifested by a significant increase in the activities of marker enzymes (AST, ALT, ALP, LDH and GGT) level in serum. The activities of enzymic (SOD, CAT, GST and GPx) and non enzymic antioxidants (VitC, Vit E and GSH) were reduced by the antitubercular drugs. Pretreatment of rats with eugenol reversed these altered parameters to near normal values. Results of this study revealed that eugenol encounter a significant defend in the mitigation of isoniazid and rifampicin induced hepatotoxicity.
PDF file:
Announcement
IJMCE RECOMMENDATION
ONLINE PAYPAL PAYMENT
CURRENT ISSUE
NEWS
CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR
Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France
Monthly archive
- May 2021
- April 2021
- March 2021
- February 2021
- January 2021
- December 2020
- November 2020
- October 2020
- September 2020
- August 2020
- July 2020
- June 2020
- May 2020
- April 2020
- March 2020
- February 2020
- January 2020
- December 2019
- November 2019
- October 2019
- September 2019
- August 2019
- July 2019
- June 2019
- May 2019
- April 2019
- March 2019
- February 2019
- January 2019
- December 2018
- 1 of 5
- ››
Advantages of IJCR
- Rapid Publishing
- Professional publishing practices
- Indexing in leading database
- High level of citation
- High Qualitiy reader base
- High level author suport
Copyright @ 2010 International Journal Of Current Research. All rights reserved
