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Probiotic potentials of lactobacillus and its anti cancer activity

Author: 
Vidya, S. and Thiruneelakandan, G.
Subject Area: 
Health Sciences
Abstract: 

Cancer is still a challenging diseases of human community mainly because of the inability of the modern medicine. We can state several reasons for the inability of modern medicine. The most challenging aspects are the development of resistance to the cytotoxic agents, side effects of the drugs used to treat cancer, the ability of cancer cells to behave like stem cells acquiring mesenchymal characteristics during metastasis. So our aim of the research is to formulate a natural drug, which acts as a potential anticancer agent without any side effects. The lactobacilli strains were isolated from the marine environment. The strains were sequenced for 16srRNA and compared with available data in NCBI. Among the strains isolated 7 of them proved to be new. The crude protein was isolated from the bacteria and treated as anticancer drug for in-vivo studies in tumour induced hamster models. Promising results were obtained; the drug decreased the tumor volume to a considerable amount and increased the life span of the animal model without any side effects when compared to the control models.

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