Maternal lifestyle is a key determinant of maternal health in the global world. Maternal health has become the top most priorities for the United Nations, the World Health Organization, Governments and institutions around the world. As a result many attempts have been made in order to improve maternal health by educating the pregnant women on their way of life, nature of diet and the kind of activities they engage themselves in during the period of pregnancy. World including, Sub- Saharan African countries specifically, Ghana has worked harder in order to achieve the millennium development goal target of improving maternal health, thereby reducing maternal mortality ratio by ¾ in 2015 (Report from Ghana Millennium Development Goals, 2008). The researched work was a quantitative study; with the helped of probit model the field data was analyzed. The study used a sample size of 200 pregnant women. The study employed both purposive and random sampling technique in taking the data. Purposively the area under study was selected in order to get the required respondents at Kwabre East District: Asonomaso Government Hospital. But in selecting the pregnant women in the study area a simple random sampling techniques was used. The study found out that, there was a negative effects of the number of period females spend on education (i.e. knowledge or absent of ignorance) and age of the pregnant women on drinking lifestyle, smoking lifestyle but exhibited a positive effect on the use of mosquito net, regular exercise and visitation of antenatal care among pregnant women. The study recommended that the Government of Ghana and all other stakeholders which include NGOs, Ghana Health service should educate the pregnant women on the use of treated mosquito net and the need to do regular exercises as well as visiting the antenatal for care. Thus, all stakeholders should engage the mass media (i.e. radio stations, television and internet) massively, to campaign and promote education for females and also inform the public to widen their knowledge on the relevance of prenatal care, post natal care, and hospital delivery, in order to reduce maternal death during delivery. Again, the study recommended that, the Government of Ghana together with all stakeholders should institute affirmative measures and actions that will encourage ladies (i.e. girls) to attend school.