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Promising veterinary oncology: “Development of an innovative self-expanding metallic colonic stent system for minimally invasive treatment of canine and feline’s colon cancer"

Author: 
Dr. Pramod Kumar Minocha, Dr. Deveshkumar Mahendralal Kothwala, Dikshita Yogendrashigh Lodha, Unnati Girish Patel and Mansi Samir Desai
Subject Area: 
Life Sciences
Abstract: 

Colon cancer, a disease similar to its human counterpart, also affects animals, including pets such as canines and felines. This malignant disease involves the uncontrolled growth of malignant cells in the tissues of the colon, a central section of the large intestine responsible for absorbing nutrients and water from digested food. The causative factors for colon cancer in animals remain complex and include genetic predisposition, dietary influences, inflammation, and possible environmental influences. Characteristic symptoms of colon cancer in animals include changes in bowel habits, hematochezia, weight loss, abdominal discomfort, decreased appetite, and lethargy. When colorectal cancer or related health problems are suspected in pets, timely veterinary intervention is essential. Timely diagnosis and appropriate medical treatment greatly improve the prognosis and management of the disease. This research article presents a new approach in the treatment of colon cancer. A self-expanding metallic colon stent system is presented, which consists of a nitinol alloy wire developed using the braiding technique. The stent has free wire ends to enhance stability and anchoring during expansion. This innovative approach strategically displaces tumors during expansion, improving colonic passage. While this study enhances our understanding of the commonalities of colon cancer in animals and humans, it highlights a breakthrough technique that holds promise for new therapeutic strategies. A critical evaluation performed in-house at laboratory scale to avoid significant risk to patient safety, stent integrity, and long-term durability has demonstrated the compressive strength of a self-expanding metallic colon stent system. This analysis has confirmed the mechanical strength of the system.

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