Quantitative estimation and comparative study of serum albumin levels in healthy and chronic periodontitis patients

Background: Serum albumin is negative acute phase protein and might be the practical marker of general health status of patient. Albumin concentration is associated with nutritional and inflammatory status of individual. Periodontitis is a chronic inflammatory disease caused by bacterial infection of periodontium. Aims: The aim of this study was to evaluate the relationship between periodontal health status and serum albumin levels. Material and Methods: Total 100 subjects irrespective of gender, with age range of 40–70 years were included in the study. Patients were divided into two groups. Group I: clinically healthy Subjects and Group II: patients with chronic periodontitis and loss of attachment ≥5 mm. Serum albumin concentration was estimated by bromocresol green albumin method. Results: Mean value of serum albumin level for Group I was 4.710g/dL with standard deviation (SD) of 0.127 and for Group II, the mean value of serum albumin level was 4.125g/dL (SD 0.128). The difference between serum albumin level in Group I and Group II were found to be statistically significant (P ≤ 0.001). Conclusions: The findings of this clinical study suggest an inverse relationship and statistically significant correlation between the serum albumin concentration and chronic periodontal disease.