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A rare case report of erosive lichen planus of tongue treated with lycopene

Author: 
Dr. Gopal Sharma, Dr. Deepa Das, Dr. Jaya Mukherjee and Dr. Bhagyashri Purandare
Subject Area: 
Health Sciences
Abstract: 

Erosive mucosal lichen planus is a painful and disabling inflammatory skin disease that is highly resistant to topical treatment.Treatment is difficult: topical corticosteroids are usually prescribed first, but antimalarial agents, oral retinoids, systemic corticosteroids, immunosuppressive drugs, and even extracorporeal photo chemotherapy can be necessary in severe cases. There is a need for novel therapies that are effective and produce less morbidity. Lycopene’s role in the management or prevention of oral lichen planus (OLP) has not been investigated. However, as significantly decreased levels of lycopene have been reported in patients with atrophic and erosive OLP, its role in the disease pathology needed further investigation. Further, by virtue of its antioxidant and anticancer properties, it may be useful in the prevention of malignant transformation in the OLP. In this case report, we present a case of 55 yr old Indian female with erosive lichen planus of tongue successfully managed with systemic lycopene.

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