The recent chronic-intensive use and dynamic future of Statins : Risks vs benefits

The increased HMGco A reductase therapy in the field of cardiovascular disease can be well explained by potent LDL and total cholesterol lowering ability. About 5 to 7.78 percentage of Indian population receiving daily statin therapy. Since statins are less suspected for its long term events, the improved understanding of long term effects of commonly used statins are necessary to reduce the accumulation of drug induced complications in hospitals. Long term effects of statins include neuropsychiatry adverse effects like cognitive impairment, dementia and short term memory loss. Diabetics, risk of carcinoma, interstial lung disease, and myopathy were few among vast data. In CAD and CKD patients, long-term statin therapy reduced the rates ADR and death rates and also statins can decrease the intra-hepatic vascular resistance in a cirrhotic liver and improves the flow mediated vasodilatation of liver vasculature. In the treatment of neurological diseases like multiple sclerosis, stroke and Parkinsonism statins shows a benefited effect. Statins are used for treating endometriosis, excessive angiogenesis and invasion of endometrial endothelial cells which is associated with locally elevated inflammatory cytokinesis. The improved understanding of long term effects of commonly used statin can considerably reduce accumulating drug induced complications in hospitals.