Introduction: Comparative study of recovery after sevoflurane versus desflurane anaesthesia in adult patients during the surgery and side effects observed during and after anaesthesia. Materials and Methods: Patients in the age group of 20-55 years, having ASA 1 and ASA 2, scheduled for elective surgery were included &randomly divided into two groups’ i.e Group I-Sevoflurane receiving group and Group II-Desflurane receiving group and patients with clinically significant cardiovascular & a history of allergic reactions to drugs were excluded. Observations and Results: At induction, a sudden rise observed in mean heart rate of patients in Group I showing a significant intergroup difference (p<0.001). It was observed that at induction mean heart rate of Group II was significantly lower as compared to that of Group I (p<0.001) whereas at 70 min, 80 min, 90 min and 100 min time intervals respectively mean heart rate in Group II was significantly higher as compared to that of Group I (p<0.05). After induction, a significant fall in both mean SBP and DBP were observed in both the groups but the fall was higher in Group II as compared to Group I thus leading to a significant difference between two groups (p<0.001). Nausea & vomiting was the most common side effect while sore throat and headache were some of the less common side effects. No significant difference was observed between two groups for any of the side effects. Conclusion: It can be concluded that both drugs provided similar intraoperative condition during maintenance period but early recovery was more rapid with Desflurane compared to Sevoflurane.
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