Retrospective observational comparative study on drug utilization of proton pump inhibitors vs h2 receptor blockers

Aim of study: The objective of the study was to assess the retrospective observational comparative study on drug utilization of proton pump inhibitors Vs H2 receptor blockers. Methodology: 150 patients are included in this study. All the patients were undergoing Proton Pump Inhibitors and H-2 receptor blockers therapy and/or co – morbidities were included in the study. The study was conducted in the General Medicine Unit (IPD), Intensive Care Unit, Surgery, Orthopedic and all other departments in a multispecialty tertiary care hospital. The patient’s demographic status like name, age, gender, occupation, address, IP number and date of admission of patients. Etc., were collected. The patient’s lifestyle profile was collected by individual patients by direct interaction with the patients or with their care takers for any lifestyle modifications. The patient’s Proton Pump Inhibitors and H-2 receptor blockers medication prescribed by the physician, along with the dosage was recorded. The appropriateness of Proton Pump Inhibitors and H-2 receptor blockers drugs like Dose, Dosage form, Duration of treatment, Route and frequency of administration with standard guidelines was also recorded. Results: Results of patient population included in the study are out of 150 males 98(65%) and females 52 (35%) are using Anti-Ulcer drugs. Based on hospitalization condition in total study population for fever and pain condition Pantoprazole (9%) given in 14 prescriptions and Ranitidine (11%) given in 16 prescriptions. In total study population based on dose and dose frequency Pantoprazole (PPI) 40mg O.D is prescribed in 17% of prescriptions and Ranitidine (H2RA) 150mg B.D is prescribed in 14% prescriptions. Based on use of Anti-Ulcer drugs in NSAID prophylaxis in total study population Pantoprazole (PPI) is prescribed in 17% prescriptions and Ranitidine (H2RA) is prescribed in 13% prescriptions.