Marine microorganism has required setting up opinion based on bioactive metabolites and approaches a unique possibility to both enhance the amount of aquatic natural foodstuffs in clinical trials as well as speed up their progress. This review focuses especially on those molecules originated from marine microorganism these days in the medical pipeline that have been expected or highly required to be identified based on growing casual confirmation .especially karlotoxin class compound isolated from din flagellate karlodinium veneficum offer chances to create new molecules for control of cancer and high serum cholesterol levels.