A human activity constitutes the physical, cultural and perceptual attributes of townscapes that creates social phenomenon and sense of place. However, human activities in historic waterfront were facing alteration which resulted to place declining and placelessness. This paper discusses the roles of human activities setting that characterized the cultural & heritage waterfront identity of those three waterfronts namely as of Venice waterfront, Amsterdam waterfront and Marsaxlokk waterfront. A case study method was conducted by some evidence such as photo observation, and study on documents analysis and other resources related to collect society’ cultural experiences. Result indicated that human activities generated from routine activity, sociocultural, and economic vitality contributed to identity of the cultural & heritage waterfront. This outcome can be helpful for the developer, policy makers and master planner to facilitate in documenting the role of human activities setting in cultural & heritage waterfront, as well to examine the meaning of human activities setting that emphasize the sense of place and social phenomenon.