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Rp- hplc facilitated quantitative analysis of tectorigenin in the different species of iris plant and evaluation of its invitro anticancer potential

Author: 
Sajad H. Wani, Asif amin, Shahnawaz N. Sofi, Taseem A. Mokhdomi, 1Shoiab Bukhari, Qazi Parvaiz Hassan and Raies A. Qadri
Subject Area: 
Life Sciences
Abstract: 

A simple HPLC-UV-DAD method was developed for rapid identification and quantitation of tectorigenin in five species of genus Iris viz Iris crocea, Iris ensata, Iris germanica, Iris kashmeriana and Iris spuria growing wild in Kashmir valley. The analysis was performed by using Chromolith RP-18e analytical column (5 μm; 4.6 mm × 100 mm) at isocratic elution of methanol and water (30:70, v/v) with diode array detection at 265nm. The calibration curve showed good linearity (r2 > 0.998) within test ranges and recoveries were 98.2 to 101.2%. The optimized method was successfully applied for the analysis of tectorigenin in 12 samples of five species of Iris collected from different eco-geographical zones. The tectorigenin content in investigated samples was greatly variant ranging from 1.08% to 8.84% with a maximum in Iris germanica collected from Gulmarg region of Kashmir valley. The method established in this paper is simple and reliable and could easily be used for the qualitative analysis of tectorigenin in Iris species. Furthermore, to evaluate anti-cancer properties, different concentrations of tectorigenin were tested against colon cancer cell line, Caco-2 using MTT cell proliferation assay. The results showed a prominent growth inhibition in a concentration dependent manner with maximum inhibition at a concentration of 100µM.

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