A study has been undertaken to enlighten the influence of industrial and domestic sewage on the water quality parameters during postmonsoon, summer, premonsoon and monsoon in Ennore creek. The concentrations of the water quality parameters especially the nutrients were above the permissible limits of the coastal standards. Total alkalinity, pH and dissolved oxygen were below the coastal standards. The stations 3 and 4 at the Ennore creek had contributed the ubiquitous distribution of nutrients in the creek. The monsoon season experienced chaotic concentrations of nutrients. Along the creek concentrations of nutrients and other water quality parameters could have been controlled by the anthropogenic inputs from point and non-point sources.