CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

A solution to combat aminoglycoside and quinolone resistant gram negative organisms

Author: 
Manu Chaudhary and Anurag Payasi
Subject Area: 
Health Sciences
Abstract: 

This study was carried out to know the prevalence of aminoglycoside and quinolone resistance among the collected isolates and to analyze the antibiotic susceptiblity patterns of various drugs against these isolates to find which drug offers the best solution against multidrug resistant Gram negative pathogens. Total 1824 clinical samples were collected from patients suspected of bacterial infection between March 2013 to May 2014. These samples were subjected for bacterial identification. The prevalence of aminoglycoside and fluoroquinolone among these isolates and antibiotic susceptibility testing were carried out according to the recommendations of Clinical Laboratory Standards Institute (CLSI) guidelines. Among the samples analyzed, 82.2 % (1499/1824) samples showed the growth of organisms of which 22 % (400/1824) were Gram positive and 60.2 % (1099/1824) were Gram negative and included in this study. Further analysis of Gram negative organisms revealed that 46.7% (513/1099) were aminoglycoside and 53.3% (586/1099) were quinolone resistant. Among Gram negative organisms that identified were E. coli (n=302), P. aeruginosa (n=230), Acinetobacter species (n=217) K. pneumoniae (n=150), Proteus species (n=109) and Citrobacter species (n=91). Of the drugs tested, cefepime plus amkacin (Potentox) showed the highest activity against quinolone and aminoglycoside resistant Gram negative organisms with average susceptibility of >86% against all pathogens. Resistance to cefepime was 55%-74%, to tobramycin 20.8%-70.2%, to gentamycin 40%-65.6%, to levofloxacin 32.9%-62.4%, to moxifloxacin 40.1%-47.7%, to ofloxacin 29.9%-48.6%, to imipenem plus cilastatin 30%-60%, to ciprofloxacin 52.3%-75.7%, to ceftazidime 50.3%-60%, to azithromycin 40.5%-86%, and to amikacin 40.4%-79.7% among all isolated Gram negative bacterial pathogens. In conclusion, the results of this study strongly suggest the superiority of Potentox over other drugs and can be of effective alternative to treat infections caused by multi drug resistant Gram negative bacteria.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran