Medicinal plants have been an integral part of life in various regional communities for food and drug. The use of medicinal plants to treat human diseases has its root in pre historical times. The aim of the present study was to investigate the ethnomedicinal uses of various plant species in three villages of Poovanur, Velukudi and Lakshmangudi from Needamagalam Taluk, Thiruvarur District. The present study reports a total number of 79 species used to cure various oilments like antidiabetics, diarrhoea and dysentery, Gastrointestinal order, Rheumatism, wounds and skin diseases. The findings provide support for the use of the plant in traditional medication.