In this research paper the researcher analyzes the effect of neuroticism personality in empty nest syndrome in middle aged women. 480 women were selected from twin city of Bhilai and Durg. The data was collected by using Empty Nest Syndrome Questionnaire and Personality Test Questionnaire. Mean, Standard Deviation and ANOVA were used for analyzing the data. The finding reveals that neuroticism it is not found that who has more feeling of empty nest syndrome neurotic people or emotionally stable people.