
Antimicrobial activity of the methanol extracts from the internal shell of L. duvauceli and S. pharaonis were tested against eight pathogenic bacteria namely Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Aeromonoas hydrophila, Streptococcus pyogenes, Vibrio fischeri, Klebsiella pneumonia, Escherichia coli and one fungal strain Candida albicans by well diffusion method. The methanol extracts of Loligo duvauceli was found to be effective against Streptococcus pyogenes, Klebsiella pneumonia, Aeromonoas hydrophila, Vibrio fischeri, Escherichia coli and Candida albicans. The cuttle bone extract showed maximum antibacterial activity (19mm) against Aeromonoas hydrophila and Escherichia coli and a minimum activity of 15mm was recorded against Streptococcus pyogenes. The results suggested that the antimicrobial activity was higher in the bone extract of S.pharaonis than L. duvauceli. A correct understanding and utilization may lead to use this waste material as a valuable pharmaceutical agent and can control pathogenic bacteria which cause dreadful human diseases.