Aim: To assess the level of anxiety and spirituality among cancer patients under radiation therapy at selected hospitals, Tirupati. Materials and Methods: A descriptive study was conducted with structured questionnaire to assess the anxiety and spirituality among cancer patients at selected hospital, Tirupati. The sample size is 100 cancer patients. Results: Among 100 cancer patients related to anxiety 34.0% had mild anxiety, 41.0% had moderate anxiety, 25.0% had sever anxiety. Related to spirituality, 26.0% had mild spirituality, 41.0% had moderate spirituality and 33.0% had sever spirituality. Conclusion: The author was concluded that, there is an importance of integrating mental health care along with cancer treatment for the patients taking longer-term treatment.