Cancer is a broad group of various diseases, all involving unregulated cell growth. Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues. Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Objectives: To assess the knowledge on Prostate cancer among school teachers, to find out the association between level of knowledge on Prostate cancer with selected demographic variables. Methodology: The research approach used for the present study was Quantitative Approach and research design was Cross-Sectional Descriptive Design. The sample of the study chosen by Non-Probability Purposive Sampling Technique, which includes 100 school teachers. A self structured questionnaire was used to collect the data which consists of 30 dichotomous questions. Results: The major findings of the study was out of 100 school teachers 51 (51%) had adequate knowledge, 35 (35%) had moderate knowledge and only 14 (14%) had inadequate knowledge regarding Prostate cancer. The associations of demographic variables with the level of knowledge on prostate cancer were determined by using chi-square test which revealed that there was a significant association with education of the school teachers, type of job, residence, habit of alcoholism, type of diet. Conclusion: The study concluded that majority of school teachers had adequate knowledge on prostate cancer. Hence there is a need to improve the knowledge regarding preventive measures for prostate cancer. So informational booklet has been given for improving knowledge and practices.