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Surfactant activity disorders and correction in acute lung injuries
Subject Area:
Health Sciences
Abstract:
A In acute lung injuries there is depression of surfactant activity, exacerbating respiratory failure. Experimental and clinical studies have shown that the main mechanism to reduce the surfactant activity is toxic pulmonary edema with the lung vessels porosity increase, allowing toxic substances to pass into the alveoli followed by inactivation of the surfactant. Exogenous surfactant preparations used are also inactivated by these toxic agents. Detoxification therapy is more pathogenetically justified, which helps to eliminate toxic porosity of the pulmonary vessels and resolve respiratory distress syndrome, including in newborns, without the need for exogenous surfactant preparations.
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