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Synthesis, characterization and antibacterial activity of 2-(1, 2, 3 –benzotrizol -1-yl-acetate) thiazolidine acetic acid ethyl ester using diethyl acetylene dicarboxylate (dead) with thiosemicarbazone derivatives

Author:

Nandhikumar, R., Dr. Subramani, K. and Dr. Syed Shafi, S.

Subject Area:

Physical Sciences and Engineering

Abstract:

In the present investigation newer and simple synthetic methods of 2- (1, 2, 3- benzotriazol -1- yl – methyl) thiozolidine acetic ethyl ester is described. Benzotriazole 1 is converted to carbothioamide 3 by reaction with ethylchloroacetate followed by thiosemicarbazide. The compound 3 is converted t o corresponding thiazolidine compound by treatment with Diethyl Acetylene Dicarboxylate (DEAD) With Thiosemicarbazone Derivatives. Structural elucidation is accomplished by IR, and 1 H NMR spectral data of the synthesized compounds. Based on the antibacterial studies of the compound 1 and 2, it can be concluded that compound 2 showed (plate-1)high activity against Escherichia coli (gram -negative bacteria) at 100µgconcentration then compound 1.

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