CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2019

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

 

 

 

 

 

 

 

 

 

 

 

Synthesis, characterization and evaluation of anticancer activity of some novel 4-thiazolidinone derivatives

Author: 
Asish Bhaumik, Upender Kumar M., Kaleem Ahmed Khan and Ch. Srinivas
Subject Area: 
Health Sciences
Abstract: 

The objective of the present work was the synthesis of N-(2-(4-substituted phenyl)-4-oxo-1,3-thiazolidine-3-yl)-2-(naphthalene-2-yloxy)acetamide and evaluation of in-vitro anticancer activity. Based on this a new series of compound had been planned to synthesize by reacting β-naphthol, ethyl chloroacetate, hydrazinemonohydrate, ethylalcohol and various aromatic aldehydes in presence of anhydrous potassium carbonate The synthesized compounds were characterized by IR, NMR, and Mass spectroscopy. The in-vitro anticancer studies were carried out against Human Acute Monocytic Leukemia - HL- 60 cell line and Human Breast Carcinoma- MCF- 7 cell lines and MTT assay was used to analyze the cell growth inhibition of the both. The results showed that compound A3, A4, A2, A5, A1,and A6 were possessed a very good anticancer activity (at 20 µg/ml) against both Human Acute Monocytic Leukemia - HL- 60 cell line and Human Breast Carcinoma- MCF- 7 cell lines and doxorubicin (at 10µg/ml) was used as a standard drug for both cancer cell lines. The IC50 values for the synthesized compounds were found to be A3 (IC50 of 2.4µg/ml), A4 (IC50 of 2.6µg/ml), A2 (IC50 of 2.9µg/ml), A5 (IC50 of 3.4µg/ml), A1(IC50 of 3.9µg/ml) and A6 (IC50 of 4.5µg/ml) against Human Acute Monocytic Leukemia - HL- 60 and A3 ( IC50 of 2.3µg/ml), A4 (IC50 of 2.6µg/ml), A2 (IC50 of 2.7µg/ml), A5 (IC50 of 3.3µg/ml), A1(IC50 of 3.1µg/ml) and A6 (IC50 of 4.5µg/ml) against Human Breast Carcinoma- MCF- 7.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

 

 

 

 

 

 

 

 

 

 

 

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran