
Schizophyllum commune is an edible and medicinal mushroom. It is a very good nutritional source of proteins, vitamins, lipids and minerals. This mushroom has been considered as the popular food and an effective medicine to treat several diseases. In the present investigation the strain Schizophyllum commune was collected from Microbial Type Culture Collection at Chandigarh. The sample was maintained in Malt Yeast Extract Broth. The cell free filtrate used for biosynthesis of silver nanoparticles. The UV-visible studies indicated the surface Plasmon resonance at 343 nm which depicts the formation of silver nanoparticles. The synthesized nanoparticles showed an effective antibacterial activity against pathogens of gram positive and gram negative bacteria. The above study will concluded that the nanoparticles had potent effect on inhibiting methicillin resisitant bacteria.