Twenty seven endometritic cows were divided into three groups to evaluate the comparative efficacy of intra-uterine Lenovo-AP and systemic antibiotic INTACEF Tazo 3375mg in endometritis of crossbred cows. Significant differences observed between the pre- and post-treatments mean values of TLC, Lymphocyte, Neutrophil, TEC and Hb in the cows of treatment groups. Milk yield was increased significantly in both the treated groups after completion of treatment. The conception rate was 88.90%, 66.70% and 11.10% in Lenovo-AP, INTACEF Tazo treated and control group, respectively. IU Lenovo-AP performed better in resolving endometritis than INTACEF Tazo and increase in milk yield level without any change in nutrition and managemental practices may be considered as an indicator of recovery of treatment.