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Is there any association of periodontitis and rheumatoid arthritis in relation to biomarkers tumor necrosis factor alpha and rheumatoid arthritis factor?

Author: 
Abdur Rehman, Sara Mukhtar, Hina Mahmood, Maimoona Nasreen, Qurat-ul-ain Leghari, Muhammad Shoaib and Ayesha Siddique
Subject Area: 
Health Sciences
Abstract: 

Background: Although the etiologies of periodontitis and rheumatoid arthritis are different, the similar underlying pathological processes are sufficient to permit consideration of hypothesis that individuals at risk of developing rheumatoid arthritis can also be at risk of developing periodontitis and vice versa. TNF-a and RA factor are amongst the important biomarkers that could be measured to launch a link between periodontitis and rheumatoid arthritis. Aim: The aim of this study is to evaluate the periodontal condition of the patients with rheumatoid arthritis and to correlate the status of periodontitis to clinical laboratory parameters like TNF-a and RA factor. Methods: A total of 120 individuals was recruited for this study according to inclusion and exclusion criteria and were divided into four groups. Patients having rheumatoid arthritis “RA” (30), patients having periodontitis “P” (30), patients having rheumatoid arthritis with periodontitis “RAP” (30) and healthy controls “C” (30). Written informed consent was taken from each individual participating in this study prior to performing any examination or sample collection. Oral examination was done for all patients prior to the sampling. Patient’s serum sample was collected, labeled, stored and analyzed for the selected biomarkers (serum TNF-a and RA factor) by using Human Bone Magnetic Bead Panel (Millipore) and ELISA. Results: Multiple comparisons were made to know the possible variation in concentrations of TNF-a and RAF between all four groups (RA, P, RAP and C). Serum levels of TNF-a and RA factor in all four groups were also assessed and intergroup analysis was done. The levels of TNF-a and RA factor has not shown significant variation among all groups. Conclusion: A better understanding of the intracellular proteins and signaling pathways that regulate TNF-a biosynthesis is crucial for the development of novel anti-TNF-based therapies for rheumatoid arthritis patients.

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