This investigation examines uptake of heavy metals, Zinc and Nickel in the tissues of the fish, Cyprinus carpio exposed to lethal and sublethal concentrations of Singanallur waste water for 3,10 & 20 days. The concentration of zinc varied from 0.29mg / gm to 0.72mg / gm (Liver), 0.56mg / gm to 0.58mg / gm (Kidney), 0.33mg / gm to 0.52mg / gm (Muscle) and Nickel concentration was varied from 0.54mg / gm to 1.60mg / gm (Liver), 10.81mg / gm to 3.63mg / gm (Kidney) and 0.75mg / gm to 1.31mg / gm (Muscle). Accumulation of Zinc was increased progressively on 3,10 & 20 days in the following order: Muscle> Kidney>Liver. In the case of nickel the order was: Liver>Muscle>Kidney. Zinc and Nickel were found to be toxic to the fish, which will biomagnify up the foodchain and will ultimately be toxic to human beings.