Toxicological study of lufenuron of the histopathologicaln and hplc. of seleted organs in the mice

The present study was planned to compare the histopathological and residual effects of the lufenuron on the liver and kidney of albino mice. Administration of dosage 0.8 unit to albino mice with one-tenth of their median lethal dose for three months (day by day), the toxicants were withdrawn for 60 days to allow recovery from toxicity. The histopatholoical investigation indicated that the dose caused venous congestion in the liver, focal necrosis of hepatocyates in the portal and periportal areas. Many of the hepatocytes are pale-stained and a few exhibit early vacuolation. Also, several cells show histological features of necrosis. Kidney exhibited inflammatory cell infiltration, congestion and hypercellularity of the glomeruli. The HPLC examination indicated residual effect in liver and kidney. This study showed that lufenuron caused histopathological effects in liver and kidney tissues even after the recovery period. The histopathological changes are due to residual effects of lufenuron in liver and kidney.