In this review we introduced for the first time in literature a new drug FSLYM 192050, patent No. 698/2014). A new method for treatment of infertility (Glyoxalase – 1 loaded Bee venom nano particles targeted with a follicle stimulating hormone peptide as a new modality in the treatment of female and male infertility). A new (name, theories, treatment) for old problem (intravenous leiomyomatosis) again we introduced Bee venom Bee propolis, Zamzam Water, Eye Tears, and EPREX, in the treatment of many reproductive aberration and updated treatment of endometriosis (NANO GOLD, NANO SILVER, Peripheral blood mononuclear cells, Yeast betaglycan, and anti CD 147 Anew mechanism of action of Dineogest) all these innovations help to improve a fetomaternal health and well being and will cause a revolution in the field of treatment of infertility.