Main purpose of this research is Analyzing effectiveness of science curriculum with teaching- based practices and research- based practices in terms of essential knowledge and skills in elementary period. This research is done with semi- experimental method with a sample containing 50 girl students in elementary third grade in Urmia City that are selected randomly and with multilevel- cluster sampling with the hypothesis of science curriculum with teaching- based practices and research- based practices. For data collecting a post- test was used with validity accepted by experts and 68% reliability and an activity observing check list was used with a validity accepted by experts and 98%reliability. In this research according to comparison of two teaching- based and research- based education methods U Mann- Whitney test was used. Research findings indicated that there are significant differences in knowledge and skills level between students who are educated with teaching- based practices and those that are educated with research- based practices and research hypothesis were accepted in 95% confidence level. As a result, science curriculum in elementary stage is more effective with research- based practices than teaching- based practices.