CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Antioxidant and invitro cytotoxicity of toddalia asiatica l

Author: 
Gopi Krishna, S., Sudarsanam, G. and Penchala Pratap, G.
Subject Area: 
Life Sciences
Abstract: 

Whole plant of Toddalia asiatica were selected to evaluate antioxidant activities and invitro cytotoxic activity using commonly accepted assays. They were extracted with chloroform, methanol and petroleum ether respectively and selected for the best antioxidant and cytotoxic results. Flavonoids, such as quercetin, rutin, and antioxidant BHA (Butylated Hydroxyanisole) were included and used as standards in this study. For all the assays concentrations of samples are maintained from 62.5 to 1000 µg/ml. Each sample under assay condition showed a dose-dependent antioxidant effect of DPPH (1,1-diphenyl-2-picryl hydrazyl radical), FRAP (Ferric reducing ability of plasma) and LPO (Lipid peroxidation inhibitory activity). Among the crude plant extracts, Methanol extract showed stronger IC50 values in antioxidant studies in DPPH and LPO methods. IC50 of Methanolic extract in DPPH is 500 ±0.00 followed by Pet.ether and Chloroform, IC50 of Pet.ether extract in LPO is 300±0.00 followed by Chloroform and Methanol. Overall FRAP absorbance range is 0.051 – 0.472, all the extracts showed moderate reducing power. The extracts also showed dose dependent cytotoxic effect on normal (Vero) and cancer cell lines (HaCaT,A549,HeLa,HT-29) when analyzed by MTT assay. Of the different crude extracts, extracts demonstrated maximum cytotoxicity to cancer cell lines, CTC50 values ranging from 116.67± 5.8 to 710 ± 10, and all the extracts showed high toxicity toward normal cell line Vero. Nearly all cancer cells could be killed by extracts, where as small fractions of cells from cancer cell lines showed resistance even at much higher concentrations.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran