Introduction: Each cardiac drug has its own pharmacological properties and side effects. Medication safety is a major concern and global issue related to the quality and safety of patient care. The administration of medication is an important aspect of nurse’s professional practice. So, nurses should update their knowledge to improve the quality of nursing care. Materials and Methods: A descriptive cross sectional research study was designed to assess the knowledge regarding common cardiac drugs among the staff Nurses in Cardiac units and to identify the factors associated with the level of knowledge about common cardiac drugs among the staff nurses in cardiac unit. The sample included 40 staff nurses who fulfilled inclusion criteria. Convenience sampling technique was used to select sample. The data collection was done by using a self-administered questionnaire. Results: Out of 40 staff nurses, four (10%) had excellent knowledge, 23 (57.5%) had good level of knowledge, 12 (30%) had average knowledge and only one had poor knowledge on common cardiac drugs. There was no significance relationship between knowledge scores and selected demographic variables like age, sex, year of experience, qualifications and area of work. Conclusion: Cardiac nurses should therefore be equipped with updated knowledge on various aspects of drug administration.