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Clinical significance of urinary microalbumin estimation in diabetic patients with co-morbid of hypertension and renal insufficiency

Author: 
Junaid Mahmood Alam, Humaira (Howrah) Ali, Ishrat Sultana, Mehwish Amin and Syed Riaz Mahmood
Subject Area: 
Health Sciences
Abstract: 

Background: Microalbuminuria is a significant clinical outcome of diabetic nephropathy and related hypertension. Moreover, diabetes mellitus is a known dangerous metabolic disorders, resulting into induction of complications such as cardiovascular, glomerular hyperfusion and end stage renal disease (ESRD). Aim and Objectives: Objectives of this study are 1) to determine the prevalence of microalbuminuria in selected age groups of diabetic patients, 2) to determine correlation of microalbumin with hypertension and renal insufficient in male and female patients. Materials and Research Design: A total of 240 subjects (n = 160 diabetic patients, n = 80 controls) were selected for present study and classified according to gender, age, clinical categories (renal insufficiency and hypertension) and control groups. Urinary microalbumin was analyzed in 2nd morning urine of all selected patients and control groups by TINA-QUANT (Roche-Diagnostics) albumin methodology on Cobas 6000 c501 analyzer. Results: Variable concentrations of microalbumin were detected in urine samples of male and female diabetic patients in both hypertensive and renal insufficiency co-morbids. Furthermore age-dependency on the correlation of microalbumin was noted, depicted by higher level of urinary microalbumin in older subjects as compared to younger ones. Conclusion: Micro-albuminuria was noted to be more prevalent in renal insufficient diabetic patients as compared to hypertensive diabetics. Additionally age-dependency was also factor in higher levels microalbuminuria.

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