Substance Use Disorder is conquering the younger generation of our world with a mighty hand of Multi Substance prevalence. The problem of substance use disorder is universal and in India, nearly 55,000 Adolescents per day are drawn into tobacco usage (Child Line). Substance Usage is high not only in the urban cities of India but also in villages. Substance has penetrated even the farthest corners of India. This Study attempts to compare the prevalence of substance use disorder among adolescents of an Urban Slum and a Village. The study was carried out in two areas (one urban slum – Chetpet and one Village – Vengal) with 30 respondents from each area selected through snowball sampling. The study finds that adolescents of the study areas are very much vulnerable to substance usage due to high availability of substance and varied influences and exposure to substance. It describes the physical, psychological and social issues faced by the substance using respondents. This paper gives a comparison of the prevalence and consequences of substance use disorder among adolescents of an urban slum and a village.