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Design and evaluation of fast dissolving tablets of sitagliptin phosphate monohydrate

Author:

Rubina Reichal, C and Gopal Rao, M.

Subject Area:

Health Sciences

Abstract:

The core objective of the study was to design and evaluate fast dissolving tablets of Sitagliptin Phosphate Monohydrate. Fast dissolving or disintegrating tablets were prepared by the wet granulation method by using Sodium Starch Glycolate, Microcrystalline Cellulose, Crosscarmellose Sodium as superdisintegrants. The prepared tablets were evaluated for pre-compression and post compression parameters. The in-vitro release studies were carried out by using USP Type-II dissolution apparatus. The selected optimized batches were kept for stability studies at 40° c ±2 °c/75%± 5%RH for a period of three months. All the results obtained were found to be satisfactory and within the limits. The results of in-vitro drug release study showed that formulation F6 exhibited good and fast disintegrating time within 12 seconds.

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