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The effect of soy milk with varying doses against acne Vulgaris

Author: 
PuguhRiyanto, PrasetyowatiSubchan and Rosa Lelyana
Subject Area: 
Health Sciences
Abstract: 

Background: Acne vulgaris (AV) is a skin disorder that is most common, with a multifactorial pathogenesis, but some studies have shown that dihydrotestosterone (DHT) is an androgen that is most instrumental in ductal hyperproliferation pilosebaseus and hypersecretion of the sebaceous glands. Soy milk are phytoestrogens which proved an antiandrogen and anti-inflammatory. The purpose of this study demonstrate the effect of soy milk on AV lesions in female patients. Methods: This study is a clinical study design with randomized pretest-posttest control group design, with 25 samples were randomized into 5 groups: soy milk 200 ml, 400 ml, 600 ml, 800 ml, and placebo, for 4 weeks, conducted a double-blind manner . Results: The study found differences in the mean total AV lesions before treatment among the five groups (p : 0.259) or not significant (p>0.05), whereas after treatment (p : 0.001) or significant (p<0.05). Differences decrease in the mean total AV lesion before and after the inter-group obtained soy milk 800 ml group (p < 0.05), while the placebo, 200 ml, 400 ml, 600 ml not significant (p>0.05), and the difference in total lesion delta AV (p:0.001) or significant (p<0.05). Conclusion: This study of soy milk supplementation 800 ml/day can lower total AV lesion.

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